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The Inserm Unit UMR 1069, "Niche, Nutrition, Cancer, and Oxidative Metabolism," is at the intersection of the two fields nutrition and cancer, based on the concept that cancer arises from complex interactions between the host and the tumor. The team focuses on dietary lipids (polyunsaturated fatty acids, ether lipids, cholesterol, and cardiolipins) as well as synthetic lipids, exploring their roles in cancer development and progression.
The unit investigates several types of cancer, including breast, colon, lung, ovarian, and prostate cancers, as well as hematological malignancies. The identified lipids are studied for their potential to prevent or reduce dysplasia, tumor progression (relapse and metastasis), resistance to treatments (chemotherapy, antibody therapies, and hormone therapy), and cancer-associated malnutrition.
Our translational and clinical research is structured around two main mechanistic axes:

1. Calcium Signaling
2. Energy and Oxidative Metabolism

The Inserm Unit UMR 1069 is composed of a multidisciplinary team of researchers, clinicians, engineers and technicians, with complementary expertise in clinical oncology, nutrition, physiology, experimental biochemistry, pharmacology and molecular biology.

Our team

48

Permanent Professors, associate Professors,
4 full time researchers (2 Inserm, 1 CHU et 1 University)
(22 HDR)

11

Post-docs, PhD Students, ATER

 

19

Engineers and technical staff

 

Ion channel signaling in health and disease

June 23, 2025 - June 26, 2025

Ion channels and calcium signaling fulfill the most critical functions in all eukaryotic cells. They underlie electrical signals central to sensory, cognitive, cardiac, endocrine and exocrine functions. They mediate critical signal transduction pathways that touch every aspect of life : development, muscle contraction, secretion,  release of neurotransmitters, hormones, metabolic activity, gene transcription, memory, pain sensation, fertilization, cell differentiation, cell migration and programmed cell death.

This meeting will showcase the latest insights and discoveries in the field of ion channels and Ca2+ signaling in particular.

Access to the lab :
Inserm UMR1069 N2COx Faculty of Medicine
Dutrochet building - 1st, 2nd and 4th floors
10 boulevard Tonnellé 37032 Tours Cedex (France)

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