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The Inserm Unit UMR 1069, "Niche, Nutrition, Cancer, and Oxidative Metabolism (N2COx)" is at the intersection of the two fields nutrition and cancer, based on the concept that cancer arises from complex interactions between the host and the tumor. The team focuses on dietary lipids (polyunsaturated fatty acids, ether lipids, cholesterol, and cardiolipins) as well as synthetic lipids, exploring their roles in cancer development and progression. The unit investigates several types of cancer, including breast, colon, lung, ovarian, and prostate cancers, as well as hematological malignancies. The identified lipids are studied for their potential to prevent or reduce dysplasia, tumor progression (relapse and metastasis), resistance to treatments (chemotherapy, antibody therapies, and hormone therapy), and cancer-associated malnutrition.
Our translational and clinical research is structured around two main mechanistic axes:

1. Calcium Signaling
2. Energy and Oxidative Metabolism

The Inserm Unit UMR 1069 is composed of a multidisciplinary team of researchers, clinicians, engineers and technicians, with complementary expertise in clinical oncology, nutrition, physiology, experimental biochemistry, pharmacology and molecular biology.

Our team

48

Permanent Professors, Associate Professors,
4 full time Researchers (2 Inserm, 1 CHU et 1 University)
(22 HDR)

19

Engineers and Technical Staff
(1 Inserm) 

 

13

Post-doctoral Researchers, ATER, PhD Students

 

Obtention d'un financement PLBio 2026 de l'Inca 

Développement d’anticorps innovants de type VHHs ciblant les canaux SKCa en cancérologie

S. Jähnichen, Public domain, Wikimedia Commons

NANOSKCan project coordinated by Pr Marie Potier-Cartereau

This exciting achievement marks an important step forward for our research, and we are particularly pleased to embark on this project alongside an outstanding team of collaborators:
�� Franck Verrecchia Equipe 9 CHILD - CRCI2NA (CHromatin and transcrIptionaL Deregulation in pediatric bone sarcoma) - Inserm Grand Ouest - Nantes Université
�� Eric Reiter BIOS Team, UMR 1282, INRAE Val de Loire - CNRS - Université de Tours
�� Anne di Tommaso ISP (Infectious Diseases and One Health), INRAE Val de Loire - Université de Tours

We would also like to thank our past and current funding partners: LabEx MAbImprove , Inserm Grand Ouest , Université de Tours, Région Centre-Val de Loire, Cancéropôle Grand Ouest, and Ligue contre le cancer. Their continued support has been instrumental in making this research possible.
�� A special thank you to Institut national du cancer for supporting this project and for its ongoing commitment to advancing ambitious and innovative cancer research. 

#CancerResearch #INCa #PLBIO2026 #ResearchFunding #Innovation #CollaborativeResearch #Oncology #UniversityOfTours #Inserm #Cancer

Access to the lab :
Inserm UMR1069 N2COx Faculty of Medicine
Dutrochet building - 1st, 2nd and 4th floors
10 boulevard Tonnellé 37032 Tours Cedex (France)

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